ADMA and oxidative stress may relate to the progression of renal disease: rationale and design of the VIVALDI study

Rainer H Böger (1) , Edzard Schwedhelm (1) , Renke Maas (1) , Sabine Quispe-Bravo (2) , Cord Skamira (2)

1 UKE - Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg]
2 Boehringer Ingelheim Pharma GmbH

The renin angiotensin system has been shown to be involved in the patho genesis of vascular and renal sequelae of diabetes mellitus. In type 2 diabetes mel litus, angiotensin receptor blockers have been shown to exert clinical benefit by reducing the progression of diabetic nephropathy. They also improve endothelium- mediated vascular function. The latter effect is partly due to the reduction of angiotensin II-associated oxidative stress. Moreover, small clinical studies have shown that treatment with angiotensin receptor blockers also reduces the circulating levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthase.

Mots clés: endothelium; 8-iso-prostaglandin F2; nitric oxide; risk marker; telmisartan

Rainer H Böger, Edzard Schwedhelm, Renke Maas, Sabine Quispe-Bravo, Cord Skamira. ADMA and oxidative stress may relate to the progression of renal disease: rationale and design of the VIVALDI study. Vascular Medicine, 2005, 10 (1), pp.S97-S102. ⟨10.1177/1358836X0501000114⟩. ⟨hal-00571352⟩