Properties of Zinc Releasing Surfaces for Clinical Applications

G. Lusvardi (1) , G. Malavasi (1) , L. Menabue (1) , M.C. Menziani (1) , A. Pedone (1) , U. Segre (1) , V. Aina (2) , A. Perardi (2) , C. Morterra (2) , F. Boccafoschi (3) , S. Gatti (3) , M. Bosetti (3) , M. Cannas (3)

1 UNIMORE - Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia
2 Department of Chemistry IFM and Centre of Excellence NIS
3 Department of Clinical and Experimental Medicine

Two series of glasses of general formula (2-p) SiO·1.1NaO·CaO·pPO·xZnO (p=0.10, 0.20; x=0.0, 0.16, 0.35, and 0.78) have been analyzed for physico-chemical surface features before and after contact with simulated body fluid, morphological characteristics, and osteoblast-like cells behavior when cultured on them. The resulted good cell adhesion and growth, along with nonsignificant changes of the focal contacts, allow the authors to indicate HZ5 and HP5Z5 glasses as the ones having optimal ratio of Zn/P to maintain acceptable cell behavior, comparable to the bioactive glass (Bioglass) used as a control; results are also rationalized by means of three-dimensional models derived by molecular dynamic simulations, with decomposition and conversion rates optimized with respect to the parent Hench's Bioglass.

Mots clés: bioactive glass; zinc; osteoblasts; cell adhesion and proliferation; focal contacts; molecular dynamics.; molecular dynamics

G. Lusvardi, G. Malavasi, L. Menabue, M.C. Menziani, A. Pedone, et al.. Properties of Zinc Releasing Surfaces for Clinical Applications. Journal of Biomaterials Applications, 2008, 22 (6), pp.505-526. ⟨10.1177/0885328207079731⟩. ⟨hal-00570784⟩