Hyper-alkalinization without hyper-hydration for the prevention of high-dose methotrexate acute nephrotoxicity in patients with osteosarcoma

Olivier Mir (1) , Stanislas Ropert (1) , Antoine Babinet (1) , Jérôme Alexandre (1) , Frédérique Larousserie (1) , Jean-Philippe Durand (1) , Eric Enkaoua (2) , Philippe Anract (1) , François Goldwasser (1)

1 Hôpital Cochin [AP-HP]
2 CHU Pitié-Salpêtrière [AP-HP]

Mots clés: Pharmacokinetics; High-dose methotrexate; Nephrotoxicity; Outpatient; Osteosarcoma; Sarcoma

Olivier Mir, Stanislas Ropert, Antoine Babinet, Jérôme Alexandre, Frédérique Larousserie, et al.. Hyper-alkalinization without hyper-hydration for the prevention of high-dose methotrexate acute nephrotoxicity in patients with osteosarcoma. Cancer Chemotherapy and Pharmacology, 2010, 66 (6), pp.1059-1063. ⟨10.1007/s00280-010-1259-3⟩. ⟨hal-00568280⟩