Role of Serum and Glucocorticoid-Regulated Kinase-1 in the protective effects of erythropoietin during renal ischemia/reperfusion injury

Krisztina Rusai , Ágnes Prókai , Beáta Szebeni , Andrea Fekete , András Treszl , Ádám Vannay , Veronika Müller , György Reusz , Uwe Heemann , Jens Lutz , Tivadar Tulassay , Attila J. Szabó

Erythropoietin (EPO) protects the kidneys from ischemia/reperfusion (I/R) injury; however, the exact signalling mechanisms are not fully understood. The serum and glucocorticoid-regulated kinase 1 (SGK1) is an anti-apoptotic protein kinase regulated through the phosphatidylinositol 3-kinase (PI3-kinase) pathway by cellular stimuli, hormones and growth factors. The objective of the present study was to examine the role of SGK1 in the renoprotective effects of EPO in renal I/R injury.

Mots clés: EPO; apoptosis; hypoxia; ischemia/reperfusion; kidney; SGK1

Krisztina Rusai, Ágnes Prókai, Beáta Szebeni, Andrea Fekete, András Treszl, et al.. Role of Serum and Glucocorticoid-Regulated Kinase-1 in the protective effects of erythropoietin during renal ischemia/reperfusion injury. Biochemical Pharmacology, 2010, 79 (8), pp.1173. ⟨10.1016/j.bcp.2009.11.022⟩. ⟨hal-00565095⟩