Hepcidin induction limits mobilisation of splenic iron in a mouse model of secondary iron overload

Emilie Camberlein , Emmanuelle Abgueguen , Nadia Fatih , François Canonne-Hergaux , Patricia Leroyer , Bruno Turlin , Martine Ropert , Pierre Brissot , Olivier Loréal

Venesection has been proposed as a treatment for hepatic iron overload in a number of chronic liver disorders that are not primarily linked to mutations in iron metabolism genes. Our was to analyse the impact of venesection on iron mobilisation in a mouse model of secondary iron overload.

Mots clés: CRP; D0 and D22; Fpn; HAMP; HFE; HIC; HJV; SIC; TFR2; liver; iron overload; hepcidin; ferroportin

Emilie Camberlein, Emmanuelle Abgueguen, Nadia Fatih, François Canonne-Hergaux, Patricia Leroyer, et al.. Hepcidin induction limits mobilisation of splenic iron in a mouse model of secondary iron overload. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2010, 1802 (3), pp.339. ⟨10.1016/j.bbadis.2009.12.007⟩. ⟨hal-00560301⟩