Doxycycline Failure Treatment of Lymphogranuloma venereum

Frédéric Méchaï (1) , Bertille de Barbeyrac (2) , Olivier Aoun (1) , Audrey Merens (1) , Patrick Imbert (1) , Christophe Rapp (1)

1 HIA Begin - Hôpital d'Instruction des Armées Begin [Saint-Mandé, France]
2 Centre national de référence. Université Victor Segalen

The number of Lymphogranuloma venereum (LGV) cases is currently reemerging in the homosexual community, particularly in HIV seropositive patients. The standard treatment for this infection caused by Chlamydia trachomatis L1, L2 and L3 serotypes is a 3 week doxycycline regime. We report the case of a male patient presenting with an LGV and rapidly cured by moxifloxacin after an initial clinical failure following an extended therapy with cyclines. This fluoroquinolone is known to be highly active in vitro on the LGV pathogenic agent. Thus, it could represent a useful alternative to doxycycline in case of failure.

Mots clés: C.TRACHOMATIS; DOXYCYCLINE

Frédéric Méchaï, Bertille de Barbeyrac, Olivier Aoun, Audrey Merens, Patrick Imbert, et al.. Doxycycline Failure Treatment of Lymphogranuloma venereum. Sexually Transmitted Infections, 2010, 86 (4), pp.278. ⟨10.1136/sti.2009.042093⟩. ⟨hal-00557470⟩