KIF21B as a shared susceptibility locus between inflammatory bowel disease and multiple sclerosis

An Goris (1) , Steven Boonen (1) , Marie-Béatrice d'Hooghe (2) , Bénédicte Dubois (1)

1 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
2 National MS Center Melsbroek

Knowledge of genetic susceptibility to autoimmune disorders is growing exponentially. One of the messages emerging from these data is the growing overlap in genetic susceptibility to different autoimmune disorders. is a member of the kinesin superfamily and was recently established as a susceptibility locus for inflammatory bowel disease and multiple sclerosis. We here replicate the association with multiple sclerosis in a Belgian study population of 791 patients and 1098 controls. As SNPs in increase risk for both inflammatory bowel disease and multiple sclerosis, this suggests a common pathway in the pathogenesis of these diseases.

Mots clés: Multiple sclerosis

An Goris, Steven Boonen, Marie-Béatrice d'Hooghe, Bénédicte Dubois. KIF21B as a shared susceptibility locus between inflammatory bowel disease and multiple sclerosis. Journal of Medical Genetics, 2010, 47 (11), pp.775. ⟨10.1136/jmg.2009.075911⟩. ⟨hal-00557390⟩