primary radiotherapy in Progressive optic nerve sheath meningiomas. A long-term follow-up study
Résumé
Abstract Background/aims: To report the outcome of primary radiotherapy in patients with progressive optic nerve sheath meningioma (ONSM). Methods: The clinical records of all patients were reviewed in a retrospective, observational, multicentre study. Results: Thirty-four consecutive patients were included. Twenty-six women and eight men received conventional or stereotactic fractionated radiotherapy, and were followed for a median 58 months (range 51–156). Fourteen eyes (41%) showed improved visual acuity of at least two lines on the Snellen chart. In 17 (50%) eyes, the vision stabilised, while deterioration was noted in three eyes (9%). The visual outcome was not associated with age at the time of radiotherapy (p = 0.83), gender (p = 0.43), visual acuity at the time of presentation (p = 0.22), or type of radiotherapy (p = 0.35). Optic disc swelling was associated with improved visual acuity (p < 0.01), and 4/11 patients with optic atrophy also showed improvement. Long-term complications were dry eyes in five patients, cataracts in three, and mild radiation retinopathy in four. Conclusion: Primary radiotherapy for patients with ONSM is associated with long-term improvement of visual acuity and few adverse effects. Keywords: Optic nerve sheath meningioma, Radiotherapy, Orbital neoplasm
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