Multidrug-resistant : mechanisms of virulence and resistance

Nicola C. Gordon (1) , David W. Wareham (1, 2)

1 Division of Infection
2 Barts & The London School of Medicine and Dentistry

Infection due to has become a significant challenge to modern healthcare systems. The organism shows a formidable capacity to develop antimicrobial resistance, yet the clinical impact of infection remains unclear. Much is known about the processes involved in multidrug resistance, but those underlying the pathogenicity and virulence potential of the organism are only beginning to be elucidated. In this article, we provide an overview of current knowledge, focusing on mechanisms of pathogenesis, the molecular basis of resistance and options for treatment in the absence of novel therapeutic agents.

Mots clés: Acinetobacter baumannii; Antimicrobial resistance; Pathogenesis

Nicola C. Gordon, David W. Wareham. Multidrug-resistant : mechanisms of virulence and resistance. International Journal of Antimicrobial Agents, 2010, 35 (3), pp.219. ⟨10.1016/j.ijantimicag.2009.10.024⟩. ⟨hal-00556384⟩