Enterovirus Markers and Serum CXCL10 levels in children with Type 1 Diabetes
Résumé
Patients with type 1 diabetes are considered to have a T-cell mediated autoimmune disease. The chemokine CXCL10 promotes the migration of activated T-cells. Virus infections might contribute to the pathogenesis of type 1 diabetes and enterovirus protein and/or genome have been detected in beta-cells from a majority of children with type 1 diabetes. Since CXCL10 is a chemokine known to be induced by virus infections, our aim was to study if levels of CXCL10 is elevated in serum from children with type 1 diabetes and whether it correlates to the presence of enterovirus markers. CXCL10, neutralizing antibody titre rises against enterovirus, and antibodies against GAD65 were measured in serum from 83 type 1 diabetes patients, 48 siblings and 69 controls. The CXCL10 serum levels were not elevated in children with type 1 diabetes and there was a considerable overlap between the groups with 99 (8-498) pg/ml in serum from children with type 1 diabetes, 120 (17-538) pg/ml in serum from controls and 117 (7-448) pg/ml in siblings of the children with type 1 diabetes. CXCL10 serum levels in patients with other virus infections were clearly elevated 418 (34-611) pg/ml. The mean CXCL10 serum levels were not elevated in patients with type 1 diabetes neither in patients with proven enterovirus infection. In contrast, in patients with other virus infections the CXCL10 levels were elevated. This suggests, that local production of CXCL10 in the affected organ cannot be measured reproducible in serum and that its potential use in clinical practice is limited.
Origine : Fichiers produits par l'(les) auteur(s)
Loading...