Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone

Teijo I. Saari (1) , Juha Grönlund (1) , Nora M. Hagelberg (1) , Mikko Neuvonen (2) , Kari Laine (3) , Pertti J. Neuvonen (2) , Klaus T. Olkkola (1)

1 Department of Anesthesiology, Intensive Care, Emergency Care and Pain Medicine
2 Department of Clinical Pharmacology
3 Department of Pharmacology, Drug Development and Therapeutics

Mots clés: CYP enzymes; Intravenous/oral drug administration; Itraconazole; Opioid effects; Oxycodone; Pharmacodynamics; Pharmacokinetics

Teijo I. Saari, Juha Grönlund, Nora M. Hagelberg, Mikko Neuvonen, Kari Laine, et al.. Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone. European Journal of Clinical Pharmacology, 2010, 66 (4), pp.387-397. ⟨10.1007/s00228-009-0775-8⟩. ⟨hal-00555614⟩