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Article Dans Une Revue Journal of Theoretical Biology Année : 2009

Elucidation of T cell signalling models

Résumé

A potential mechanism that allows T cells to reliably discriminate pMHC ligands involves an interplay between kinetic proofreading, negative feedback and a destruction of this negative feedback. We analyse a detailed model of these mechanisms which involves the TCR, SHP1 and ERK. We discover that the behaviour of pSHP1 negative feedback is of primary importance, and particularly the influence of a kinetic proofreading base negative feedback state on pSHP1 dynamics. The CD8 co-receptor is shown to benefit from a kinetic proofreading locking mechanism and is able to overcome pSHP1 negative influences to sensitise a T cell.
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Dates et versions

hal-00554653 , version 1 (11-01-2011)

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Nick D.L. Owens, Jon Timmis, Andrew Greensted, Andy Tyrrell. Elucidation of T cell signalling models. Journal of Theoretical Biology, 2009, 262 (3), pp.452. ⟨10.1016/j.jtbi.2009.10.017⟩. ⟨hal-00554653⟩

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