Individual cell-based models of cell scatter of aro and mlp-29 cells in response to hepatocyte growth factor

Marco Scianna (1, 2) , Roeland M.H. Merks , Luigi Preziosi (1) , Enzo Medico (2)

1 Department of Mathematics
2 Department of Oncological Sciences and Laboratory of Oncogenomics

The different behaviors of colonies of two cell lines, ARO (tyroid carcinoma-derived cells) and MLP-29 (Mouse Liver Progenitor cells), in response to Hepatocyte Growth Factor (HGF) are described deducing suitable Cellular Potts Models (CPM). It is shown how increased motility and decreased adhesiveness are responsible for cell-cell dissociation and tissue invasion in the ARO cells. On the other hand, it is shown that, in addition to the biological mechanisms above, it is necessary to include directional persistence in cell motility and HGF diffusion to describe the scattering and the branching processes characteristic of MLP-29 cells

Mots clés: Cellular Potts Model; Hepatocyte Growth Factor; ARO cell line; Cell-cell dissociation; Invasive growth; MLP-29 cell line; Scattering

Marco Scianna, Roeland M.H. Merks, Luigi Preziosi, Enzo Medico. Individual cell-based models of cell scatter of aro and mlp-29 cells in response to hepatocyte growth factor. Journal of Theoretical Biology, 2009, 260 (1), pp.151. ⟨10.1016/j.jtbi.2009.05.017⟩. ⟨hal-00554613⟩