Information encoding and pathways in basal ganglia neurons
Résumé
The decision making process is a phenomenon which is hard to track using the standard signal averaging methods such as peri-event time histograms (PETHs). Indeed, even if the sequence of the events is controlled during a behavioural task, the inter-event interval duration remains highly variable. We have applied a temporal normalization method such that PETHs can be mapped across all events of a task trial and compared from neuron to neuron and from session to session. We have also applied Shannon mutual information theory to compare neural activity in recorded striatum and GPi neurons in behaving monkeys during a centre-out motor task and investigated individual neuron coding properties. These methods illustrate information pathways and their relative involvement. We also show that the GPi neurons recorded during the decision phase contained more information about the context and choice combination than striatal neurons.
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