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Communication Dans Un Congrès Année : 2010

Stable frequency response to varying stimulus intensity in a model of the rat olfactory bulb

Résumé

In the rat olfactory bulb (OB), fast oscillations of the local field potential (LFP) are observed during the respiratory cycle. Gamma-range oscillations (60Hz) occurat the end of inspiration, followed by beta-range oscillations (15-20Hz) during exhalation. These oscillations are highly stereotyped, and their frequencies are stable under various conditions. Here we investigate the effect of stimulus intensity on activity in the OB. Using a double canulation protocol, we show that, although the frequency of the LFP oscillation does depend on the respiratory cycle, it is relatively independent from the intensity of odorant stimulation. In contrast, we found that the individual firing rate of mitral OB cells changes greatly with the intensity of the stimulation. Using a computer model of the OB, where fast oscillations are generated by the interplay between excitatory mitral/tufted cells, and inhibitory granule cells, we found that the difference between individual and population responses can be explained by the role of sub-threshold oscillations in the MCs. Sub-threshold oscillations of the MCs stabilize the frequency of the population oscillation, and allow their firing rate to vary without affecting the population frequency.
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Dates et versions

hal-00553417 , version 1 (10-03-2011)

Identifiants

  • HAL Id : hal-00553417 , version 1

Citer

Thomas Voegtlin, Corine Amat, Virginie Briffaud, Nathalie Buonviso, Emmanuelle Courtiol, et al.. Stable frequency response to varying stimulus intensity in a model of the rat olfactory bulb. Cinquième conférence plénière française de Neurosciences Computationnelles, "Neurocomp'10", Aug 2010, Lyon, France. ⟨hal-00553417⟩
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