Brain atrophy and lesion load measures over one year relate to clinical status after 6 years in patients with clinically isolated syndromes

Massimiliano Di Filippo (1) , Valerie M Anderson (1) , Daniel R Altmann (1) , Josephine K Swanton (1) , Gordon T Plant (2) , Alan J Thompson (1) , David H Miller (1)

1 NMR Research Unit [London]
2 Neuro-ophthalmology Clinic, Moorfields Eye Hospital

Conventional MRI lesion measures modestly predict long term disability in some CIS studies. Brain atrophy suggests neuroaxonal loss in MS with the potential to reflect disease progression to a greater extent than lesion measures.

Mots clés: MRI; MULTIPLE SCLEROSIS

Massimiliano Di Filippo, Valerie M Anderson, Daniel R Altmann, Josephine K Swanton, Gordon T Plant, et al.. Brain atrophy and lesion load measures over one year relate to clinical status after 6 years in patients with clinically isolated syndromes. Journal of Neurology, Neurosurgery and Psychiatry, 2010, 81 (2), pp.204. ⟨10.1136/jnnp.2009.171769⟩. ⟨hal-00552764⟩