Specific effects exerted by B-lymphoproliferative diseases on peripheral T-lymphocytes protein expression

Marina Borro (1, 2) , Giovanna Gentile (1, 2) , Ottavia de Luca (2) , Laura Aimati (2) , Maria Simona Torre (2) , Caterina Tatarelli (3) , Maria Antonietta Aloe Spiriti (3) , Maria Christina Cox (3) , Maurizio Simmaco (1, 2)

1 2nd Faculty of Medicine
2 Unit of Advanced Molecular Diagnostics
3 Haematology

A proteomic approach was applied to study the protein expression profile of peripheral T-cells derived from patients at the onset of different B-lymphoproliferative diseases, since a rising interest in specific actions played by T-cells in such pathologies has emerged. Decreased levels of profilin-1 and cofilin-1 and increased levels of coronin1A and prohibitin were found in patients, compared with healthy controls. The protein-protein interaction network of these proteins was studied using a web-based bioinformatics tool, highlighting the actin cytoskeleton regulation as the main biological process involved in peripheral T-cells of such patients. Unsupervised cluster analysis of protein expression data shows that the recorded alteration of T-cell proteome was specifically induced by B-cells pathologies.

Mots clés: Medicine

Marina Borro, Giovanna Gentile, Ottavia de Luca, Laura Aimati, Maria Simona Torre, et al.. Specific effects exerted by B-lymphoproliferative diseases on peripheral T-lymphocytes protein expression. British Journal of Haematology, 2010, ⟨10.1111/j.1365-2141.2010.08285.x⟩. ⟨hal-00552603⟩