Outcome of adults with sickle cell disease admitted to critical care – Experience of a single institution in the UK

Kate Gardner (1) , Cathy Bell (2) , Jack Luke Bartram (1) , Marlene Allman (3) , Moji Awogbade (3) , David C Rees (1) , Ian Maxwell Ervine (2) , Swee Lay Thein (4)

1 Department of Paediatric Haematology [London]
2 Anaesthetics
3 Haematological Medicine
4 Division of Gene and Cell Based Therapy

Patients with sickle cell disease (SCD) are perceived to have a high mortality when admitted to critical care. We performed a retrospective analysis of all adult sickle admissions to Critical Care Unit (CCU) at a single centre over an eight year period between 1 January 2000 to 31 December 2007. Thirty eight patients (14 male) were admitted 46 times to CCU; the commonest reasons for admission were acute chest syndrome (14, 30%), multi-organ failure (8, 17%) and planned post-elective surgery (7, 15%). CCU mortality for patients with SCD was 19.6%, comparable to a CCU-wide mortality of 17.6% during the study period in the same institution. Re-admission to critical care was high (16% over the eight year period) but did not increase mortality risk.

Mots clés: Medicine

Kate Gardner, Cathy Bell, Jack Luke Bartram, Marlene Allman, Moji Awogbade, et al.. Outcome of adults with sickle cell disease admitted to critical care – Experience of a single institution in the UK. British Journal of Haematology, 2010, 150 (5), pp.610. ⟨10.1111/j.1365-2141.2010.08271.x⟩. ⟨hal-00552601⟩