Verification that common variation at 2q37.1, 6p25.3, 11q24.1, 15q23, and 19q13.32 influences chronic lymphocytic leukaemia risk

Dalemari Crowther-Swanepoel (1) , Mahmoud Mansouri (2) , Anna Enjuanes (3) , Ana Vega (4) , Karin Ekström Smedby (5) , Clara Ruiz-Ponte (4) , Jesper Jurlander (6) , Gunnar Juliusson (7) , Emili Montserrat (8) , Daniel Catovsky (9) , Elias Campo (10) , Angel Carracedo (4) , Richard Rosenquist (11) , Richard S Houlston (12)

1 Cancer Genetics
2 Genetics and Pathology
3 Hematopathology Unit
4 Genomic Medicine Group
5 Department of Medicine
6 Department of Hematology
7 Hematology and Transplantation
8 Department of Haematology
9 Haemato-oncology
10 Department of Pathology
11 Dept of Genetics and Pathology
12 15 Cotswold Road

A recent genome wide association study of chronic lymphocytic leukemia (CLL) has provided evidence that common variation at 2q13 (rs17483466), 2q37.1 (rs13397985), 6p25.3 (rs872071), 11q24.1 (rs735665), 15q23 (rs7176508) and 19q13.32 (rs11083846) affects CLL risk. To verify and further explore the relationship between these variants and CLL risk we genotyped case-control datasets from Spain and Sweden totaling 824 cases and 850 controls. Combined data provided statistically significant support for an association between genotypes at rs13397985, rs872071, rs735665, rs7176508 and rs11083846 and CLL risk. CLL risk was shown to increase with increasing numbers of risk alleles (Ptrend=1.40x10-15), consistent with a polygenic model of disease susceptibility. These data validate the relationship between common variation and risk of CLL.

Mots clés: Medicine

Dalemari Crowther-Swanepoel, Mahmoud Mansouri, Anna Enjuanes, Ana Vega, Karin Ekström Smedby, et al.. Verification that common variation at 2q37.1, 6p25.3, 11q24.1, 15q23, and 19q13.32 influences chronic lymphocytic leukaemia risk. British Journal of Haematology, 2010, ⟨10.1111/j.1365-2141.2010.08270.x⟩. ⟨hal-00552600⟩