The impact of high-dose methotrexate on intracellular 6-mercaptopurine disposition during interval therapy of childhood acute lymphoblastic leukemia

T. Adam de Beaumais (1) , T. Dervieux (2) , M. Fakhoury (1) , Y. Medard (1) , S. Azougagh (1) , D. Zhang (1) , K. Yakouben (3) , E. Jacqz-Aigrain (1)

1 Department of Pediatric Pharmacology and Pharmacogenetics
2 Cypress Bioscience
3 Department of Hematology

Mots clés: Methotrexate; Methotrexate polyglutamates; Mercaptopurine; Leukemia; Thioguanine nucleotides

T. Adam de Beaumais, T. Dervieux, M. Fakhoury, Y. Medard, S. Azougagh, et al.. The impact of high-dose methotrexate on intracellular 6-mercaptopurine disposition during interval therapy of childhood acute lymphoblastic leukemia. Cancer Chemotherapy and Pharmacology, 2009, 66 (4), pp.653-658. ⟨10.1007/s00280-009-1205-4⟩. ⟨hal-00552486⟩