A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

Andrew J. Massey (1) , Douglas S. Williamson (1) , Helen Browne (1) , James B. Murray (1) , Pawel Dokurno (1) , Terry Shaw (1) , Alba T. Macias (1) , Zoe Daniels (1) , Stephanie Geoffroy (1) , Melanie Dopson (1) , Paul Lavan (1) , Natalia Matassova (1) , Geraint L. Francis (1) , Christopher J. Graham (1) , Rachel Parsons (1) , Yikang Wang (1) , Antony Padfield (1) , Mike Comer (1) , Martin J. Drysdale (1) , Mike Wood (1)

1 Vernalis (R&D) Ltd

Mots clés: Hsc70; Hsp70; Hsp90; Small molecule inhibitor; Apoptosis; Combination studies; Pharmacokinetics

Andrew J. Massey, Douglas S. Williamson, Helen Browne, James B. Murray, Pawel Dokurno, et al.. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemotherapy and Pharmacology, 2009, 66 (3), pp.535-545. ⟨10.1007/s00280-009-1194-3⟩. ⟨hal-00552481⟩