14q32/miRNA clusters loss of heterozygosity in acute lymphoblastic leukemia is associated with up-regulation of BCL11a

Cecilia Agueli (1) , Giuseppe Cammarata (2) , Domenico Salemi (1) , Lea Dagnino (1) , Roberta Nicoletti (1) , Maria La Rosa (1) , Francesca Messana (1) , Anna Marfia (1) , Maria Grazia Bica (1) , Maria Luisa Coniglio (1) , Maria Pagano (1) , Francesco Fabbiano (1) , Alessandra Santoro (1)

1 Divisione di Ematologia con UTMO
2 IBIM

The present study evaluated the loss and expression level of miRNAs 14q32 clusters in ALL patients with cryptic deletions at 14q32 chromosomal band to investigate their involvement in this disease. We demonstrate that a subset of ALL cases bearing 14q32 LOH showed a down-regulation of miRNA 14q32 clusters, which is directly linked to the submicroscopic chromosomal deletion. As a consequence of miRNAs deregulation we reported an inverse correlation with the expression of their target BCL11a, a transcription factor involved in lymphoid differentiation. These results suggest that 14q32/miRNA clusters LOH may be another mechanism involved in lymphoid B cell transformation and differentiation and therefore, could be used as a diagnostic marker and therapeutic target in subsets of ALL

Mots clés: Medicine

Cecilia Agueli, Giuseppe Cammarata, Domenico Salemi, Lea Dagnino, Roberta Nicoletti, et al.. 14q32/miRNA clusters loss of heterozygosity in acute lymphoblastic leukemia is associated with up-regulation of BCL11a. American Journal of Hematology, 2010, 85 (8), pp.575. ⟨10.1002/ajh.21758⟩. ⟨hal-00552330⟩