Procalcitonin is a reliable marker of severe systemic infection in neutropenic haematological patients with mucositis - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue American Journal of Hematology Année : 2010

Procalcitonin is a reliable marker of severe systemic infection in neutropenic haematological patients with mucositis

Résumé

Patients with neutropenia are exposed to a high risk for infections in which fever is often the unique symptom (1). Systemic infections remain the main cause of mortality in these patients therefore, the policy for infection management is to promptly administer empirical antibiotic therapy in order to avoid the increased risk of mortality related to the treatment delay (2). However, microbiological diagnostic tests are not sufficiently rapid, sensitive or specific to indentify the microbial causes of fever, and a considerable number of patients suffer febrile episodes over a prolonged period without a definite microbiological aetiology. Procalcitonin (PCT) (3) has become increasingly popular as a novel marker of infection. Several studies have underscored its value in clinical conditions by identifying infectious processes (4, 5, 6). The use of this marker in haematological patients has provided controversial results and no agreement exists about the capacity of PTC to differentiate fever by other inflammatory processes such as mucositis and Graft versus Host diseases (GVHD) (7-11). In order to evaluate the usefulness of PCT in diagnostic and therapeutic approaches to fever in haematological patients, we evaluated the values of PCT, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in the course of febrile neutropenia by assessing the influence of mucositis and GVDH on these three parameters.

Mots clés

Fichier principal
Vignette du fichier
PEER_stage2_10.1002%2Fajh.21685.pdf (308.07 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-00552309 , version 1 (06-01-2011)

Identifiants

Citer

Loredana Sarmati, Angela Beltrame, Luca Dori, Gaetano Maffongelli, Laura Cudillo, et al.. Procalcitonin is a reliable marker of severe systemic infection in neutropenic haematological patients with mucositis. American Journal of Hematology, 2010, ⟨10.1002/ajh.21685⟩. ⟨hal-00552309⟩

Collections

PEER
70 Consultations
195 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More