Distinct receptor-mediated activities in macrophages for natural ceramide-1-phosphate (C1P) and for phospho-ceramide analogue-1 (PCERA-1)

Maya Levi , Michael M. Meijler , Antonio Gómez-Muñoz , Tsaffrir Zor

Ceramide-1-phosphate (C1P) is known as a second messenger regulating a multitude of processes including cell growth, apoptosis and inflammation. Exciting recent findings now suggest that C1P can stimulate macrophages migration in an extra-cellular manner via a G protein-coupled receptor (GPCR). Interestingly, a synthetic C1P analog, named phospho-ceramide analogue-1 (PCERA-1), was recently described as a potent anti-inflammatory agent, and was suggested to act on macrophages in an extra-cellular manner via a GPCR. Here we summarize and compare the receptor-mediated as well as receptor-independent activities of natural C1P and its synthetic analog. We also provide experimental data in support of distinct C1P and PCERA-1 receptors.

Mots clés: Macrophages; Inflammation; C1P; PCERA-1; phospholipid-binding receptors; Cell migration

Maya Levi, Michael M. Meijler, Antonio Gómez-Muñoz, Tsaffrir Zor. Distinct receptor-mediated activities in macrophages for natural ceramide-1-phosphate (C1P) and for phospho-ceramide analogue-1 (PCERA-1). Molecular and Cellular Endocrinology, 2009, 314 (2), pp.248. ⟨10.1016/j.mce.2009.05.007⟩. ⟨hal-00547652⟩