Signal Amplification in Biological and Electrical Engineering Systems

Vladimir Grubelnik , Bogdan Dugonik , Davorin Osebik , Marko Marhl

In this paper we compare the cascade mechanisms of signal amplification in biological and electrical engineering systems, and show that they share the capacity to considerably amplify signals, and respond to signal changes both quickly and completely, which effectively preserves the form of the input signal. For biological systems, these characteristics are crucial for efficient and reliable cellular signalling. We show that this highly-efficient biological mechanism of signal amplification that has naturally evolved is mathematically fully equivalent with some man-developed amplifiers, which indicates parallels between biological evolution and successful technology development.

Mots clés: Multi-Stage Amplifier; Protein Cascade; Cellular Signalling; Laplacean transformation

Vladimir Grubelnik, Bogdan Dugonik, Davorin Osebik, Marko Marhl. Signal Amplification in Biological and Electrical Engineering Systems. Biophysical Chemistry, 2009, 143 (3), pp.132. ⟨10.1016/j.bpc.2009.04.009⟩. ⟨hal-00545278⟩