Herd immunity tio Newcastle disease virus in poultry by vaccination

Michiel van Boven (1) , Annemarie Bouma (2) , Teun Fabri (3) , Elly Katsma (1) , Leo Hartog (4) , Guus Koch (5, 6)

1 Animal Sciences Group
2 Faculty of Veterinary Medicine
3 Animal Health Service
4 Department of Virology
5 Virology
6 Virology

Newcastle disease virus is an economically important disease of poultry for which vaccination is applied as a preventive measure in many countries. Nevertheless, outbreaks have been reported in vaccinated populations. This suggests that either the vaccination coverage level is too low or that vaccination does not provide perfect immunity, allowing the virus to spread in partially vaccinated populations. Here we study the requirements of an epidemiologically effective vaccination program against Newcastle disease in poultry, based on data from experimental transmission studies. The transmission studies indicate that vaccinated birds with low or undetectable antibody titres may be protected against disease and mortality but that infection and transmission may still occur. In fact, our quantitative analyses show that NDV is highly transmissible in poultry with low antibody titres. As a consequence, herd immunity can only be achieved if a high fraction of birds (>85%) has a high antibody titre (log2 haemagglutination inhibition titre≥3) after vaccination. We discuss the implications for the control of Newcastle disease virus in poultry by vaccination.

Mots clés: Life Sciences

Michiel van Boven, Annemarie Bouma, Teun Fabri, Elly Katsma, Leo Hartog, et al.. Herd immunity tio Newcastle disease virus in poultry by vaccination. Avian Pathology, 2008, 37 (01), pp.1-5. ⟨10.1080/03079450701772391⟩. ⟨hal-00540101⟩