Selective NF-¿B inhibition versus dexamethasone, decreases acute lung injury in a newborn piglet airway inflammation model of acute lung injury

Philipp von Bismarck , Karsten Klemm , Carlos-Francisco Garcia.Wistadt , Supandi Winoto-Morbach , Stefan Schutze , Martin F. Krause

Acute respiratory failure in neonates (e.g., ARDS, meconium aspiration pneumonitis, pneumonia) is characterized by an excessive inflammatory response, governing the migration of polymorpho-nuclear leukocytes (PMNL) into lung tissue and causing consecutive impairment of gas exchange and lung function. Critical to this inflammatory response is the activation of nuclear factor-κB (NF-κB) that is required for transcription of the genes for many pro-inflammatory mediators. We asked whether the inhibition of NF-κB activity using either a selective inhibitor (IKK-NBD peptide) or dexamethasone would be more effective in decreasing NF-κB activity and chemokine expression in pulmonary cells. Changes in lung function were repeatedly assessed for 24h following induction of acute respiratory failure and therapeutic intervention.

Mots clés: Lung inflammation; nuclear factor-κB; polymorpho-nuclear leukocytes; chemokines; dexamethasone; IKK-NBD peptide; acute lung injury; respiratory failure; newborn piglets

Philipp von Bismarck, Karsten Klemm, Carlos-Francisco Garcia.Wistadt, Supandi Winoto-Morbach, Stefan Schutze, et al.. Selective NF-¿B inhibition versus dexamethasone, decreases acute lung injury in a newborn piglet airway inflammation model of acute lung injury. Pulmonary Pharmacology & Therapeutics, 2009, 22 (4), pp.297. ⟨10.1016/j.pupt.2009.02.002⟩. ⟨hal-00540031⟩