A Novel Breath-Actuated Integrated Vortex Spacer Device increases relative lung bioavailability of Fluticasone/Salmeterol in fCombination
Résumé
Spacer devices facilitate respirable drug delivery. A novel breath actuated antistatic spacer with integrated vortex chamber (Synchro-Breathe™) device has been developed, which is compact, portable and user friendly as compared to conventional spacers which are bulky and cumbersome. The relative bioavailability to the lung of inhaled fluticasone and salmeterol combination is primarily dependant on respirable dose delivery and can be reliably quantified using adrenal suppression and early fall in serum potassium (marker of systemic beta-2 adrenoreceptor response) as surrogate markers for delivered lung dose.
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