The changing scene of allogeneic stem cell transplantation for chronic myeloid leukemia—a report from the German Registry covering the period from 1998 to 2004

Ulrike Bacher (1) , Evgeny Klyuchnikov (1, 2) , Tatjana Zabelina (1) , Hellmut Ottinger (3) , Dietrich W. Beelen (3) , Hubert Schrezenmeier (3, 4) , Gerhard Ehninger (3, 5) , Carlheinz Müller (3) , Jürgen Berger (6) , Meinolf Suttorp (7) , Hans-Jochem Kolb (8) , Nicolaus Kröger (1) , Axel R. Zander (1)

1 Interdisziplinäre Klinik für Stammzelltransplantation
2 Klinik für Stammzelltransplantation
3 Deutsches Register für Stammzelltransplantation (DRST) c/o KMT-Klinik
4 Institut für Klinische Transfusionsmedizin und Immungenetik Ulm
5 Medizinische Klinik und Poliklinik I
6 Zentrum für Experimentelle Medizin, Institut für Medizinische Biometrie und Epidemiologie
7 Klinik und Poliklinik für Kinder- und Jugendmedizin
8 III. Medizinische Klinik

Due to the recent changes in the indication to allogeneic stem cell transplantation (SCT) in chronic myeloid leukemia (CML), we retrospectively analyzed 1,716 patients with different CML stages who received an allograft from related ( = 767) or unrelated donors ( = 938) within the German Registry of Stem Cell Transplantation (DRST) from 1998 to 2004. Myeloablative conditioning was performed in 724/871 cases (83%), dose-reduced conditioning in 147/871 (17%). Annual transplantations were decreasing from 357 to 98 (28%) in the period of study, but the proportion of advanced cases was increasing from 32% (112/346) to 53% (50/94) of all SCTs. Stage of disease, intervals from diagnosis, and patients' age were independent prognostic parameters, while peripheral stem cells and unrelated transplantation seemed equal to bone marrow/related transplantation. This study demonstrates that allo-SCT still has an important role in advanced CML, which emphasizes the need for optimized transplantation strategies for these high-risk patients.

Mots clés: Allogeneic stem cell transplantation (SCT); Chronic myeloid leukemia (CML); Dose-reduced conditioning (RIC); Myeloablative conditioning; German Registry of Stem Cell Transplantation (DRST)

Ulrike Bacher, Evgeny Klyuchnikov, Tatjana Zabelina, Hellmut Ottinger, Dietrich W. Beelen, et al.. The changing scene of allogeneic stem cell transplantation for chronic myeloid leukemia—a report from the German Registry covering the period from 1998 to 2004. Annals of Hematology, 2009, 88 (12), pp.1237-1247. ⟨10.1007/s00277-009-0737-3⟩. ⟨hal-00535050⟩