Increased risk of zoonotic and gastroenteritis in patients with haematological malignancies: a population-based study
Résumé
We hypothesised that haematological malignancies increase the risk of acquiring zoonotic or gastroenteritis. The population-based study comprised all first-time / gastroenteritis cases in two Danish counties (1991–2003), with age- and gender-matched controls from the background population. We linked the study cohort to registries to obtain data on malignancies, chemotherapy (yes/no), and main comorbidities diagnosed before / gastroenteritis. Based on this design, we determined incidence rate ratios (IRR) in conditional logistic regression analyses, and we used weighted mean regression curves to evaluate fluctuations in risk 0–5 years after the malignancy diagnosis. Sixty-eight of 13,324 cases (0.5%) and 29 of 26,648 controls (0.1%) had haematological malignancy before their / gastroenteritis. Comorbidity-adjusted IRR for / gastroenteritis in patients with haematological malignancy as compared to patients without malignancy were 4.46 [95% confidence intervals (CI), 2.88–6.90] for all individuals, 8.33 (95% CI, 4.31–16.1) for , and 2.17 (95% CI, 1.15–4.08) for . Stratification on chemotherapy treatment did not change these estimates. In time-related analyses, IRR were 7–8 in the first 2 years after the haematological malignancy diagnosis and 4–5 in the following 3 years. Patients with haematological malignancy had increased long-term risk of enquiring or gastroenteritis.
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