Differential effects of anti-apoptotic Bcl-2 family members Mcl-1, Bcl-2, and Bcl-xL on Celecoxib-induced apoptosis

Justine Rudner , Simon Johannes Elsaesser , Arndt-Christian Müller , Claus Belka , Verena Jendrossek

The cyclooxygenase-2 inhibitor Celecoxib is a potent inducer of apoptosis in tumor cells. In most cellular systems Celecoxib induces apoptosis via an intrinsic, mitochondrial apoptosis pathway. We recently showed that in Bax-negative Jurkat cells expression of pro-apoptotic Bak is essential for Celecoxib-induced mitochondrial damage and apoptosis induction. Aim of the present study was to identify specific pro- and anti-apoptotic members of the Bcl-2 family involved in the regulation of Bak activation, and subsequent apoptosis upon treatment with Celecoxib in the Jurkat cell model.

Mots clés: Life Sciences

Justine Rudner, Simon Johannes Elsaesser, Arndt-Christian Müller, Claus Belka, Verena Jendrossek. Differential effects of anti-apoptotic Bcl-2 family members Mcl-1, Bcl-2, and Bcl-xL on Celecoxib-induced apoptosis. Biochemical Pharmacology, 2009, 79 (1), pp.10. ⟨10.1016/j.bcp.2009.07.021⟩. ⟨hal-00529099⟩