SYNTHESIS OF HIGH FLUORESCENT SILICA HYBRID MATERIALS BY IMMOBILIZATION OF ORANGE PEEL EXTRACT IN SILICA-SILSESQUIOXANE MATRIX
Résumé
Sol-gel chemistry has been easily modified to the changing needs of society to produce fine-tuned sol-gel nanostructured materials for relevant applications. In this respect, there is an increasing need for natural and versatile raw materials, as well as biocompatible compounds that could be extensively used as biomarkers for bioimaging in diagnostic or therapy. Silica-based materials are widely used in the field of biomedicine due to their chemical inertness and biocompatibility. In the present paper, an orange peel extract was immobilized inside inorganic silica and hybrid silica-silsesquioxane polymeric networks. Silica and organo-modified silica matrices have been synthesized through a templated sol-gel route of TEOS and an organosilsesquioxane (octaisobutyltetracyclo[7.3.3.15,11] octasiloxane-endo-3,7-diol), with D-glucose as template, and for comparisons a non-ionic surfactant (tetraethylene glycol monohexadecyl ether) has been also used. The bioactive principles contained in the molecules from orange peel extract were preserved after immobilization in both silica and silica-silsesquioxane networks. Moreover, the fluorescence properties were amplified by more than 10-20 times than native orange peel extract. The structural properties of final materials have been studied by FT-IR, UV-VIS-NIR and fluorescence spectroscopy. Dynamic Light Scattering measurements and transmission electronic microscopy were used in order to estimate the size and morphology of hybrid materials with orange peel extract immobilized in silica networks.
Origine : Fichiers produits par l'(les) auteur(s)
Loading...