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| HAL : hal-00518270, version 1 |
| Fiche détaillée |  Récupérer au format |
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| 6th International Conference on Sensitivity Analysis of Model Output, SAMO 2010, Milan : Italie (2010) |
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| Identifiability and sensitivity analysis of a Photodynamic Therapy model |
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Simona Dobre 1Thierry Bastogne 1, 2 |
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| (19/07/2010) |
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| Photodynamic therapy (PDT) is an alternative treatment for cancer that involves the administration of a photosensitizing agent, which is activated by light at a specific wavelength. The photo-toxic phase of this therapy can be described by a dynamic model composed of six nonlinear differential equations. The model parameters can be used to compare photosensitizing agents in their capability to produce cytotoxic species. The practical issue is their estimation from in vivo experimental data. In this paper, a new approach is proposed to analyze the photophysical parameters estimability through a local practical identifiability study combined with a global sensitivity analysis. Results show that only three parameters can reasonably be estimated in a given and realistic experimental framework. Input design (light signal) and model reduction are currently in progress. |
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| 1 : | Centre de recherche en automatique de Nancy (CRAN) |
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CNRS : UMR7039 – Université Henri Poincaré - Nancy I – Institut National Polytechnique de Lorraine (INPL) |
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| 2 : | BIGS (INRIA Lorraine / IECN) |
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INRIA – CNRS : UMR7502 |
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| 3 : | Centre Alexis Vautrin |
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CRLCC Alexis Vautrin |
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| 4 : | Médicaments Photoactivables - Photochimiothérapie (PHOTOMED) |
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CNRS : GDR3049 – Institut de Chimie du CNRS |
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| Domaine | : | Sciences de l'ingénieur/Automatique / Robotique Sciences du Vivant/Cancer |
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| Identifiability – sensitivity analysis – nonlinear systems – biomedical systems |
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| Liste des fichiers attachés à ce document : | |||||
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| hal-00518270, version 1 | |
| http://hal.archives-ouvertes.fr/hal-00518270 | |
| oai:hal.archives-ouvertes.fr:hal-00518270 | |
| Contributeur : Thierry Bastogne | |
| Soumis le : Jeudi 16 Septembre 2010, 23:18:55 | |
| Dernière modification le : Jeudi 24 Novembre 2011, 13:46:56 | |
