TGF-β and fibrosis in different organs - molecular pathway imprints

Dirk Pohlers , Julia Brenmoehl , Ivonne Löffler , Cornelia K. Müller , Carola Leipner , Stefan Schultze-Mosgau , Andreas Stallmach , Raimund W. Kinne , Gunter Wolf

The action of transforming-growth-factor (TGF)-β following inflammatory responses is characterized by increased production of extracellular matrix (ECM) components, as well as mesenchymal cell proliferation, migration, and accumulation. Thus, TGF-β is important for the induction of fibrosis often associated with chronic phases of inflammatory diseases. This common feature of TGF-related pathologies is observed in many different organs. Therefore, in addition to the description of the common TGF-β-pathway, this review focuses on TGF-β-related pathogenetic effects in different pathologies/organs, i. e., arthritis, diabetic nephropathy, colitis/Crohn's disease, radiation-induced fibrosis, and myocarditis (including their similarities and dissimilarities). However, TGF-β exhibits both exacerbating and ameliorating features, depending on the phase of disease and the site of action. Due to its central role in severe fibrotic diseases, TGF-β nevertheless remains an attractive therapeutic target, if targeted locally and during the fibrotic phase of disease.

Mots clés: TGF-β; fibrosis; arthritis; nephritis; inflammatory bowel disease; Crohn's disease; wound-healing; myocarditis

Dirk Pohlers, Julia Brenmoehl, Ivonne Löffler, Cornelia K. Müller, Carola Leipner, et al.. TGF-β and fibrosis in different organs - molecular pathway imprints. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2009, 1792 (8), pp.746. ⟨10.1016/j.bbadis.2009.06.004⟩. ⟨hal-00506515⟩