Neuroprotective effects of N-alkyl-1,2,4-oxadiazolidine-3,5-diones and their corresponding synthetic intermediates N-alkylhydroxylamines and N-1-alkyl-3-carbonyl-1-hydroxyureas against in vitro cerebral ischemia

A.C. Biraboneye (1) , S. Madonna (1) , P. Maher , J.L. Kraus (1)

1 IBDM - Institut de Biologie du Développement de Marseille

Mots clés: Animals; Brain Ischemia/*drug therapy; Hydroxylamines/chemical synthesis/*chemistry/therapeutic use; Hydroxyurea/chemical synthesis/*chemistry/therapeutic use; JNK Mitogen-Activated Protein Kinases/metabolism; Mice; Neuroprotective Agents/*chemical synthesis/chemistry/therapeutic use; Oxadiazoles/chemical synthesis/*chemistry/therapeutic use; p38 Mitogen-Activated Protein Kinases/metabolism; Cell Line; Extracellular Signal-Regulated MAP Kinases/metabolism

Domaines: Biologie cellulaire

A.C. Biraboneye, S. Madonna, P. Maher, J.L. Kraus. Neuroprotective effects of N-alkyl-1,2,4-oxadiazolidine-3,5-diones and their corresponding synthetic intermediates N-alkylhydroxylamines and N-1-alkyl-3-carbonyl-1-hydroxyureas against in vitro cerebral ischemia. ChemMedChem, 2010, 5, pp.79-85. ⟨10.1002/cmdc.200900418⟩. ⟨hal-00505936⟩