Zinc supplementation attenuates ethanol- and acetaldehyde-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS) production and by influencing intracellular signaling

Agnieszka Szuster-Ciesielska , Krzysztof Plewka , Jadwiga Daniluk , Martyna Kandefer-Szerszeń

Zinc has been reported to prevent and reverse liver fibrosis in vivo; however, the mechanisms of its action are poorly understood. We therefore aimed to determine the antifibrotic potential of zinc.

Mots clés: Liver stellate cells; Zinc; Cytokines; MAPK; NFκB

Agnieszka Szuster-Ciesielska, Krzysztof Plewka, Jadwiga Daniluk, Martyna Kandefer-Szerszeń. Zinc supplementation attenuates ethanol- and acetaldehyde-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS) production and by influencing intracellular signaling. Biochemical Pharmacology, 2009, 78 (3), pp.301. ⟨10.1016/j.bcp.2009.04.009⟩. ⟨hal-00493516⟩