Di-(2-ethylhexyl)-phthalate (DEHP) activates the Constitutive Androstane Receptor (CAR): a novel signalling pathway sensitive to phthalates

Alexandre Eveillard , Laila Mselli-Lakhal , Ariane Mogha , Frédéric Lasserre , Arnaud Polizzi , Jean-Marc Pascussi , Hervé Guillou , Pascal G.P. Martin , Thierry Pineau

Di-(2-ethylhexyl)-phthalate (DEHP), a widely used plasticizer, is detected in consumer's body fluids. Contamination occurs through environmental and food chain sources. In mouse liver, DEHP activates the peroxisome proliferator-activated receptor alpha (PPARα and regulates the expression of its target genes. Several investigations support the simultaneous recruitment of additional nuclear receptor pathways.

Mots clés: Toxicology; Phthalates; Endocrine disruptors; Androstane receptor; Metabolic syndrome

Domaines: Sciences du Vivant [q-bio]

Alexandre Eveillard, Laila Mselli-Lakhal, Ariane Mogha, Frédéric Lasserre, Arnaud Polizzi, et al.. Di-(2-ethylhexyl)-phthalate (DEHP) activates the Constitutive Androstane Receptor (CAR): a novel signalling pathway sensitive to phthalates. Biochemical Pharmacology, 2009, 77 (11), pp.1735. ⟨10.1016/j.bcp.2009.02.023⟩. ⟨hal-00493499⟩