Disposition of everolimus in mdr1a-/1b- mice and after a pre-treatment of lapatinib in Swiss mice

C. Chu , C. Abbara , M.S. Noël-Hudson , L. Thomas-Bourgneuf , P. Gonin , R. Farinotti , L. Bonhomme-Faivre

The aim of this study was to document the transport of everolimus (inhibitor of mTOR) by P-glycoprotein (P-gp), and to investigate the influence of lapatinib (inhibitor of P-gp) on everolimus disposition.

Mots clés: Lapatinib; Everolimus; P-glycoprotein; Pharmacokinetics; Mice

C. Chu, C. Abbara, M.S. Noël-Hudson, L. Thomas-Bourgneuf, P. Gonin, et al.. Disposition of everolimus in mdr1a-/1b- mice and after a pre-treatment of lapatinib in Swiss mice. Biochemical Pharmacology, 2009, 77 (10), pp.1629. ⟨10.1016/j.bcp.2009.02.013⟩. ⟨hal-00493494⟩