Characterization of species-related differences in the pharmacology of tachykinin NK receptors 1, 2 and 3

Agnes Leffler , Ingela Ahlstedt , Susanna Engberg , Arne Svensson , Martin Billger , Lisa Öberg , Magnus Bjursell , Erik Lindström , Bengt von Mentzer

Tachykinin NK receptors (NKR) differ to a large degree among species with respect to their affinities for small molecule antagonists. The aims of the present study were to clone NKRs from gerbil (NKR and NKR) and dog (NKR, NKR, NKR) in which the sequence was previously unknown and to investigate the potency of several NKR antagonists at all known human, dog, gerbil and rat NKRs.

Mots clés: NKR; SP; NKA; NKB; AA; FLIPR; TM; Aprepitant; Saredutant; Talnetant; NK receptors; Species difference; NK-receptor function; Chemistry; NK-receptor sequences

Agnes Leffler, Ingela Ahlstedt, Susanna Engberg, Arne Svensson, Martin Billger, et al.. Characterization of species-related differences in the pharmacology of tachykinin NK receptors 1, 2 and 3. Biochemical Pharmacology, 2009, 77 (9), pp.1522. ⟨10.1016/j.bcp.2009.01.020⟩. ⟨hal-00493489⟩