Bivalve models of aging and the determination of molluscan lifespans

Doris Abele , Thomas Brey , Eva Philipp

Bivalves are newly discovered models of natural aging. This invertebrate group includes species with the longest metazoan lifespan approaching 400 years, as well as species of swimming and sessile lifestyles that live just for 1 year. Bivalves from natural populations can be aged by shell growth bands formed at regular intervals of time. This enables the study of abiotic and biotic environment factors (temperature, salinity, predator and physical disturbance) on senescence and fitness in natural populations, and distinguishes the impact of extrinsic effectors from intrinsic (genetic) determinantes of animal aging. Extreme longevity of some bivalve models may help to analyze general metabolic strategies thought to be life prolonging, like the transient depression of metabolism, which forms part of natural behaviour in these species. Thus, seasonal food shortage experienced by benthic filter feeding bivalves in polar and temperate seas may mimic caloric restriction in vertebrates. Incidence of malignant neoplasms in bivalves needs to be investigated, to determine the implication of late acting mutations for bivalve longevity.  Finally, bivalves are applicable models for testing the implication of heterozygosity of multiple genes for physiological tolerance, adaptability (heterozygote superiority), and life expectancy.

Mots clés: Bivalve; longevity; aging; stress tolerance; heterozygosity; Antarctic; genes; metabolic rate depression

Doris Abele, Thomas Brey, Eva Philipp. Bivalve models of aging and the determination of molluscan lifespans. Experimental Gerontology, 2009, 44 (5), pp.307. ⟨10.1016/j.exger.2009.02.012⟩. ⟨hal-00493101⟩