Low activation of Insulin- Growth Factor 1-Receptor (IGF1R) is associated with local recurrence in early breast carcinoma

Gloria Peiró (1) , Susana Benlloch (1) , Laura Sánchez-Tejada (1) , Encarna Adrover (2) , Enrique Lerma (3) , Francisca M. Peiró (4) , José Sánchez-Payá (5) , F. Ignacio Aranda (4)

1 Research Unit
2 Department of Clinical Oncology
3 Pathology Department
4 Department of Pathology
5 Department of Epidemiology

The predictive value of IGF1R on local recurrence in invasive breast carcinoma (BC) is not well known. In a series of 197 lymph-node negative BC patients treated with breast-conserving surgery and radiation therapy, we performed immunohistochemistry for α-IGF1R, β-IGF1R (phosphorylated/active form) and Estrogen/Progesterone receptors. We further evaluated the IGF1R mRNA expression by quantitative RT-PCR and mutations by direct DNA sequencing (exons 19 and 21) in 85 primary BC (42 control cases, 31 with local recurrence and 12 with distant metastasis) and in 31 local recurrences. Unconditional logistic regression analyses were performed to identify risk factors for recurrence. Local recurrences were associated with high-grade tumors, PR-negative and low active-IGF1R, which emerged as independent breast relapse predictors by multivariate analysis. Patients with early BC treated with lumpectomy and radiation who have low-grade tumors and favorable markers (increased content of active IGF1R and PR-positive) have a low risk of local recurrence. Therefore, do not benefit from a boost dose on the surgical scar.

Mots clés: Early breast carcinoma; IGF1R; mRNA; Mutation

Gloria Peiró, Susana Benlloch, Laura Sánchez-Tejada, Encarna Adrover, Enrique Lerma, et al.. Low activation of Insulin- Growth Factor 1-Receptor (IGF1R) is associated with local recurrence in early breast carcinoma. Breast Cancer Research and Treatment, 2008, 117 (2), pp.433-441. ⟨10.1007/s10549-008-0139-6⟩. ⟨hal-00486594⟩