More knocks to the oxidation hypothesis for vascular disease?
Résumé
The oxidation hypothesis for coronary heart disease (CHD) is attractive. However, the almost universal failure of antioxidant vitamin supplementation as a CVD risk modifier challenges the oxidation hypothesis, at least as a concept that easily ‘translates' into clinical benefit for the population. At the same time, quality prospective data on lipid or protein oxidation markers as predictors of vascular events is spare. In this issue of the journal, Woodward and colleagues provide much needed prospective data examining the relationship between markers of oxidative damage and CHD outcome in a general population. Despite noting the expected associations between several established CHD risk factors and CHD events, no significant link was seen between measured oxidation markers and CHD risk, a finding which further challenges the oxidation hypothesis for CHD.
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