Immuno-inflammatory predictors of stroke at follow-up in patients with chronic non-valvular atrial fibrillation (NVAF)

Antonio Pinto , Antonino Tuttolomondo (1) , Alessandra Casuccio , Domenico Di Raimondo , Riccardo Di Sciacca , Valentina Arnao , Giuseppe Licata

1 Biomedical Department of Internal and Specialist Medicine

Objective: To determine rates of stroke in patients with chronic nonvalvular atrial fibrillation (NVAF) evaluating the relationship between plasma levels of inflammatory variables at admission and the occurrence of stroke during a three year follow-up. Methods: 373 consecutive patients with chronic NVAF were enrolled. Blood samples were drawn within 72 hours of admission. We evaluated plasma levels of IL-1β, TNF-α, IL-6, IL-10, E-selectin, P-selectin, ICAM-1 VCAM-1 and Von Willebrand Factor (vWF). Patient subsequent events (stroke at follow-up) were monitored over a 3 year period. Results: At multivariate analysis only age, hypertension and high levels of IL6, TNF-α and vWF remained a significant predictor of a higher risk of experiencing ischemic stroke at follow-up. Moreover, plasma values of TNF-α , IL6 and vWF showed a significant area under the ROC curve Conclusion: Baseline plasma levels of TNF-α, IL-6 and vWF are predictors of new onset ischemic stroke at follow-up in patients with chronic non valvular atrial fibrillation (NVAF).

Mots clés: Medicine

Antonio Pinto, Antonino Tuttolomondo, Alessandra Casuccio, Domenico Di Raimondo, Riccardo Di Sciacca, et al.. Immuno-inflammatory predictors of stroke at follow-up in patients with chronic non-valvular atrial fibrillation (NVAF). Clinical Science, 2009, 116 (10), pp.781-789. ⟨10.1042/CS20080372⟩. ⟨hal-00479446⟩