Immune regulator cells: circulating biomarker factories in cardiovascular disease
Résumé
Toll Like receptors are the first line of defence of the innate immune system. These receptors recognise not only exogenous but also endogenous ligands that are expressed following arterial injury and atherosclerotic disease. Expression of the Toll like receptors 2 and 4 is observed in macrophages and different vascular cells and is increased in atherosclerotic disease. It is suggested that Toll Like receptor expression and functional responsiveness following ligation could serve as biomarkers for atherosclerotic disease progression. Recently published research papers support the concept that the Toll Like receptors are fast responders upon arterial injury. In the current issue of Clinical Science new evidence emerges that point to the potential prognostic properties of the Toll like Receptors.
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