Effects of lymphotoxin-{alpha} gene and galectin-2 gene polymorphisms on inflammatory biomarkers, cellular adhesion molecules and risk of coronary heart disease
Résumé
The proinflammatory cytokine lymphotoxin-{alpha} (LTA) has multiple functions in regulation of the immune system and may contribute to inflammatory processes leading to coronary heart disease (CHD). The aim of this study was to investigate whether the common T26N and A252G polymorphisms of the LTA gene and the C3279CT polymorphism of the galectin 2 (LGALS2) gene, which affects LTA secretion, are associated with inflammatory parameters and cell adhesion molecules and whether these polymorphisms are related to CHD in US women and men. We conducted a prospective nested case-control study within the Nurses‘ Health Study and Health Professionals Follow-Up Study. Among participants free of cardiovascular disease at baseline, 249 women and 266 men developed CHD during 8 and 6 years of follow-up respectively, and we matched controls 2:1 based on age and smoking. The LGALS2 gene variant was significantly associated with a decreased risk for CHD in women (Odds ratio [95% confidence intervals]: 0.70 [0.50-0.97], p=0.03). In addition, the LGALS2 polymorphism was directly associated with C-reactive protein levels in cases from both studies (p<0.05). The LTA gene polymorphisms were directly associated with levels of soluble tumor necrosis factor receptors and vascular cell adhesion molecule-1 in both women and men with CHD (p<0.05). However, no overall effect was demonstrated between LTA gene polymorphisms and risk for CHD.
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