FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease

Spyros Zissimopoulos , N. Lowri Thomas , Wan Jamaluddin , F. Anthony Lai (1)

1 Medicine - Cardiology

In this communication, we show that distinct human RyR2 inherited mutations expressed in mammalian cells exhibit either unaltered or increased FKBP12.6 binding compared to wild-type. Oxidising conditions result in reduced FKBP12.6 binding, but to the same extent as for wild-type. Our findings suggest that FKBP12.6 regulation of RyR2 is unlikely to be the primary defect in inherited arrhythmogenic cardiac disease.

Mots clés: Life Sciences

Spyros Zissimopoulos, N. Lowri Thomas, Wan Jamaluddin, F. Anthony Lai. FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease. Biochemical Journal, 2009, 419 (2), pp.273-278. ⟨10.1042/BJ20082324⟩. ⟨hal-00479135⟩