Chloroplast membranes retard fat digestion and induce satiety: effect of biological membranes on pancreatic lipase/co-lipase - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Biochemical Journal Année : 2006

Chloroplast membranes retard fat digestion and induce satiety: effect of biological membranes on pancreatic lipase/co-lipase

Per-Åke Albertsson
  • Fonction : Auteur
Rickard Köhnke
  • Fonction : Auteur
Sinan C. Emek
  • Fonction : Auteur
Jie Mei
  • Fonction : Auteur
Jens F. Rehfeld
  • Fonction : Auteur
Hans-Erik Åkerlund
  • Fonction : Auteur
Charlotte Erlanson-Albertsson
  • Fonction : Auteur

Résumé

Human obesity is a global epidemic, which causes a rapidly increased frequency of diabetes and cardiovascular disease. One reason for obesity is the ready availability of refined food products with high caloric density, an evolutionarily new event, which makes over consumption of food inevitable. Fat is a food product with high caloric density. The mechanism for regulation of fat intake has therefore been studied to a great extent. Such studies have shown that as long as fat stays in the intestine, satiety is promoted. This occurs through the fat released peptide hormones, the best known being cholecystokinin, CCK, which is released by fatty acids. Hence, retarded fat digestion with prolonged time for delivery of fatty acids promote satiety. Pancreatic lipase, together with its protein cofactor, colipase, is the main enzymatic system responsible for intestinal fat digestion. We found that biological membranes, isolated from plants, animals or bacteria, inhibit the lipase/colipase-catalysed hydrolysis of triglycerides even in the presence of bile salt. We propose that the inhibition is due to binding of lipase/colipase to the membranes and adsorption of the membranes to the aqueous/triglyceride interface, thereby hindering lipase/colipase from acting on its lipid substrate. We also found that chloroplast membranes (thylakoids), when added to refined food, suppressed food intake in rats, lowered blood lipids and raised the satiety hormones, CCK and enterostatin. Consequently, the mechanism for satiety seems to be retardation of fat digestion allowing the fat products to stay longer in the intestine.

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Dates et versions

hal-00478671 , version 1 (30-04-2010)

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Per-Åke Albertsson, Rickard Köhnke, Sinan C. Emek, Jie Mei, Jens F. Rehfeld, et al.. Chloroplast membranes retard fat digestion and induce satiety: effect of biological membranes on pancreatic lipase/co-lipase. Biochemical Journal, 2006, 401 (3), pp.727-733. ⟨10.1042/BJ20061463⟩. ⟨hal-00478671⟩

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