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Article Dans Une Revue Biochemical Journal Année : 2006

Regulation of prokaryotic adenylyl cyclases by CO2

Arne Hammer
  • Fonction : Auteur
David Rw Hodgson
  • Fonction : Auteur

Résumé

The Slr1991 adenylyl cyclase of the model prokaroyte Synechocystis PCC 6803 was stimulated two-fold at 20 mM total inorganic carbon at pH 7.5 through an increase in k cat}. A dose response demonstrated an E.C. 50} of 52.7 mM total inorganic carbon at pH 6.5. Slr1991 was activated by CO 2} but not HCO 3} -}. CO 2} regulation of adenylyl cyclase was conserved in the CyaB1 adenylyl cyclase of Anabaena PCC 7120. These adenylyl cyclases represent the only identified signalling enzymes directly activated by CO 2}. The findings prompt an urgent reassessment of the activating carbon species for proposed HCO 3} -} activated adenylyl cyclases.

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Dates et versions

hal-00478551 , version 1 (30-04-2010)

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Arne Hammer, David Rw Hodgson, Martin J Cann. Regulation of prokaryotic adenylyl cyclases by CO2. Biochemical Journal, 2006, 396 (2), pp.215-218. ⟨10.1042/BJ20060372⟩. ⟨hal-00478551⟩

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