Voriconazole drastically increases exposure to oral oxycodone

Nora M. Hagelberg (1) , Tuija H. Nieminen (1) , Teijo I. Saari (1) , Mikko Neuvonen (2) , Pertti J. Neuvonen (2) , Kari Laine (3) , Klaus T. Olkkola (1)

1 Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine
2 Department of Clinical Pharmacology
3 Department of Pharmacology, Drug Development & Therapeutics

Mots clés: Oxycodone; Voriconazole; Cytochrome P450; CYP2D6; CYP3A; Pharmacokinetics

Nora M. Hagelberg, Tuija H. Nieminen, Teijo I. Saari, Mikko Neuvonen, Pertti J. Neuvonen, et al.. Voriconazole drastically increases exposure to oral oxycodone. European Journal of Clinical Pharmacology, 2008, 65 (3), pp.263-271. ⟨10.1007/s00228-008-0568-5⟩. ⟨hal-00477928⟩