Genotypic diversity of coagulase-negative staphylococci causing endocarditis: a global perspective.

Cathy A Petti , Keith E Simmon , Jose M Miro , Bruno Hoen (1, 2) , Francesc Marco , Vivian H Chu , Eugene Athan , Suzana Bukovski , Emilio Bouza , Suzanne Bradley , Vance G Fowler , Efthymia Giannitsioti , David Gordon , Porl Reinbott , Tony Korman , Selwyn Lang , Cristina Garcia-De-La-Maria , Annibale Raglio , Arthur J Morris , Patrick Plesiat (3) , Suzanne Ryan , Thanh Doco-Lecompte , Francesca Tripodi , Riccardo Utili , Dannah Wray , J Jeffrey Federspiel , K. Boisson , L Barth Reller , David R Murdoch , Christopher W Woods , Non Renseigné

1 Service des maladies infectieuses et tropicales
2 LCE - Laboratoire Chrono-environnement (UMR 6249)
3 API - Agents pathogènes et inflammation - UFC (EA 4266)

Coagulase-negative staphylococci (CNS) are important causes of infective endocarditis (IE), but their microbiological profiles are poorly described. We performed DNA target sequencing and susceptibility testing for 91 patients with definite CNS IE who were identified from the International Collaboration on Endocarditis-Microbiology, a large, multicenter, multinational consortium. A hierarchy of gene sequences demonstrated great genetic diversity within CNS from patients with definite endocarditis that represented diverse geographic regions. In particular, rpoB sequence data demonstrated unique genetic signatures with the potential to serve as an important tool for global surveillance.

Domaines: Maladies infectieuses

Cathy A Petti, Keith E Simmon, Jose M Miro, Bruno Hoen, Francesc Marco, et al.. Genotypic diversity of coagulase-negative staphylococci causing endocarditis: a global perspective.. Journal of Clinical Microbiology, 2008, 46 (5), pp.1780-4. ⟨10.1128/JCM.02405-07⟩. ⟨hal-00465371⟩